Table 1 Top 10 proteins with the lowest p-values in the comparison of the 7 weeks old APP^NL-G-F versus their relative wild-type (WT)

Sin3a

↘

Transcriptional repressor; required for the transcriptional repression of circadian target genes; regulate cell cycle progression; required for cortical neuron differentiation and callosal axon elongation

Cog6

↘

✓

Subunit of the conserved oligomeric Golgi complex; Required for maintaining normal structure and activity of the Golgi apparatus; Involved in protein transport

Pla2g15

↘

Lysophospholipases; Enzyme that act on biological membranes to regulate the multifunctional lysophospholipids

Hdhd5

↘

Predicted to be involved in glycerophospholipid biosynthetic process; Predicted to be active in mitochondria

Adgre5

↘

Member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors; Mediates cell–cell interactions; Plays a role in cell adhesion, in leukocyte recruitment, activation and migration, and in the binding to chondroitin sulfate and the cell surface complement regulatory protein CD55

Spcs1

↗

Component of the signal peptidase complex (SPC); Catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum; Predicted to enable peptidase activity and ribosome binding activity

Fbxo10

↘

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.; Plays a role in apoptosis, ubiquitination and subsequent lysosomal degradation

Pigu

↗

Fifth subunit of GPI transamidase complex that attaches GPI-anchors to proteins

Npr2

↘

Receptor for natriuretic peptide; Has guanylyl cyclase activity; May play a role in the regulation of skeletal growth

Slc30a1

↗

Zinc ion:proton antiporter; Mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity