The utility of customised tissue probability maps and templates for patients with idiopathic normal pressure hydrocephalus: a computational anatomy toolbox (CAT12) study

Table 1 Demographics of participants

	iNPH patients for developing study	iNPH patients for validation study	HCs	P-value
Number	114	38	25
Age (years), mean ± SD	77.4 ± 5.4	77.6 ± 3.9	66.2 ± 6.6	< 0.001^†
Sex (women/men)	55/59	18/20	13/12	0.930^‡
iNPHGS, median (25th–75th percentile)
Gait	2.0 (2.0–2.0)	2.0 (2.0–2.0)	NA	0.774^§
Cognition	3.0 (2.0–3.0)	2.0 (2.0–3.0)	NA	0.054^§
Urination	1.0 (1.0–2.0)	1.5 (1.0–2.0)	NA	0.626^§
Total	6.0 (5.0–7.0)	5.5 (5.0–7.0)	NA	0.362^§
MMSE (/30), mean ± SD	22.4 ± 4.0 (n = 111)	23.3 ± 3.0	28.6 ± 1.8	0.001^†
TUG
Time (ms), mean ± SD	12.5 ± 4.2 (n = 104)	14.3 ± 4.8 (n = 35)	NA	0.656^\|\|
Steps, mean ± SD	19.8 ± 6.9	19.3 ± 8.9	NA	0.697^\|\|
MRI scanner (number)
1.5T GE signa	77	0	14
3T TOSHIBA Vantage Titan	17	0	0
3T SIEMENS MAGNETOM Trio, A Tim System	20	0	0
3T SIEMENS MAGNETOM Vida	0	38	0
3T GE signa	0	0	11

^†The Analysis of variance, followed by Tukey’s post-hoc analysis was used. Compared to the two iNPH patients’ groups, the HCs’ group had significantly lower mean age and higher mean MMSE score. ^‡The chi-square test was used. ^§The Mann–Whitney U-test was used. ^||The student’s t-test was used
HC healthy control, iNPH idiopathic normal-pressure hydrocephalus, iNPHGS idiopathic Normal-Pressure Hydrocephalus Grading Scale, MMSE Mini-Mental State Examination, NA not assessed, TUG timed up-and-go test

ISSN: 2045-8118