Fig. 2

Aβ Pathology in Brain Samples from CNI and AD Patients. A Diffuse Aβ plaques in AD patients were 2.5-fold higher (p = 0.003) compared to diffuse Aβ plaques in CNI. B Neuritic Aβ plaques in AD patients were 2.3-fold higher (p = 0.039) than neuritic Aβ plaques in CNI. C Neuritic plaque frequency was similar for AD and CNI patients (p = 1.000). D CAA instances were more frequent and severe in AD patients (4 severe cases, 2 moderate cases, 3 mild cases) when compared with CAA instances in CNI (1 severe case, 3 moderate cases, 5 mild cases). E Brain Aβ40 levels in AD brain samples were 4.3-fold higher (p = 0.022) than in CNI brain samples. F Brain Aβ42 levels in AD brain samples were similar (p = 0.380) to those in CNI brain samples. p values were estimated by Mann–Whitney Rank-Sum test in (A–E) and by Student’s t-test with Welch’s correction in (F)