Fig. 2

Fusion of IDS with HSA or anti-serum albumin sdAbs (R28, M79) extends the serum half-life of IDS in rats. Serum concentrations of the constructs (observed versus predicted) were determined following i.v. administration at 76 nmol/kg. A20.1 VHH is rapidly eliminated and fusion with human Fc (hFc) dramatically reduced elimination from serum. IDS underwent rapid 2 phase elimination and fusion with HSA, R28 or M79 reduced elimination from serum. Values are shown as mean ± SEM