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Fig. 10 | Fluids and Barriers of the CNS

Fig. 10

From: Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival

Fig. 10

The optic nerve of Kidins220-deficient mice exhibits increased GFAP expression with decreased AQP4 content. (A) Representative fluorescence microscopy images of AQP4 (red) and GFAP (green) immunostaining in the optic nerve of WT and Kidins220f/f animals. Nuclei are labelled with DAPI (blue). (B, C). Quantitative analysis of the mean gray fluorescence value of AQP4+ (B) and GFAP+ (C) immunostaining in WT and Kidins220f/f mice. Data are mean ± s.e.m.; each data point denotes an individual measure of the mean gray value of AQP4 + and GFAP + immunostaining in retinal sections of WT and Kidins220f/f animals and were analyzed via Mann-Whitney U-test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; or Wilcoxon W-test, ####p < 0.0001. Abbreviations: Retina (R), Sclera (S), Optic Nerve (ON), Prelaminar (PL), Glial Lamina Cribrosa (GLC), Retrolaminar (RL). Upper panels: Scale bar 100 μm (10X); Lower panels: Scale bar 50 μm (20X)

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Fluids and Barriers of the CNS

ISSN: 2045-8118