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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival

Fig. 2

Kidins220 levels are decreased in the retina of Kidins220f/f deficient mice. (A) Representative fluorescence microscopy images of Kidins220 immunostaining (red) in WT and in Kidins220f/f deficient animals. The different retina layers are indicated. Nuclei are labelled with DAPI (blue). Magnified images (Zoom) are shown in the right panels. (B) Representative Kidins220 and b-actin (loading control) immunoblots of retina lysates from WT and Kidins220f/f mice and the corresponding Kidins220 levels quantification graph. Data are mean ± s.e.m.; each data point denotes one individual mouse; **p < 0.01, by two-tailed unpaired Student’s t-test. Abbreviations: ONL (Outer nuclear layer), OPL (Outer plexiform layer), INL (Inner nuclear layer), IPL (Inner plexiform layer), GCL (Ganglion cell layer). Scale bar 50 μm, zoom 10 μm

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Fluids and Barriers of the CNS

ISSN: 2045-8118