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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival

Fig. 4

Kidins220 deficiency in the retina is not associated with loss of retinal ganglion cells (RGC) or decreases in their survival. (A) Representative fluorescence microscopy images of retinas labeled for apoptotic cleaved caspase 3 + cells (red) and cells stained with the RGC specific marker Brn3a (green) in WT and in Kidins220f/f deficient animals. Nuclei are labelled with DAPI (blue). (B, C). Quantitative analysis of total number of cleaved caspase 3 + cells and Brn3a + cells, respectively, in the total retina or in different sectors - PP (peripapillary), I (intermediate), and P (peripheral) - in WT and Kidins220f/f animals. Data are mean ± s.e.m.; each data point denotes an individual measure of the number of Brn3a + cells in retinal sections of WT and Kidins220f/f animals and were analyzed via Mann-Whitney U-test. Abbreviations: ONL (Outer nuclear layer), OPL (Outer plexiform layer), INL (Inner nuclear layer), IPL (Inner plexiform layer), GCL (Ganglion cell layer). Scale bar 50 μm

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Fluids and Barriers of the CNS

ISSN: 2045-8118