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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival

Fig. 5

Increased phagocytic microglia in the mouse retina with deficits in Kidins220. (A). Representative fluorescence microscopy images of Iba-1 (red) and CD68 (green) staining to label phagocytic microglia cells in WT and in Kidins220f/f mice. Nuclei are labelled with DAPI (blue). (B, C, D). Quantitative analysis of total retinal area (RA) occupied by Iba-1 + immunostaining. (B), the number of Iba-1 + cells (C) and Iba-1+/CD68 + cells (D) in different retina layers - OS (outer segment layer), OPL (outer plexiform layer) and ICL (inner complex layer) in WT and Kidins220f/f animals. Data are mean ± s.e.m.; each data point denotes an individual measure of the Iba1 + RA, the number of Iba-1 + cells and the number of Iba-1+/CD68 + cells in retinal sections of WT and Kidins220f/f animals and were analyzed via Mann-Whitney U-test. ***p < 0.001, ****p < 0.0001. Abbreviations: ONL (Outer nuclear layer), OPL (Outer plexiform layer), INL (Inner nuclear layer), IPL (Inner plexiform layer), GCL (Ganglion cell layer). Scale bar 50 μm

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Fluids and Barriers of the CNS

ISSN: 2045-8118