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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival

Fig. 6

Increased GFAP expression in astrocytes of Kidins220-deficient retina. (A). Representative fluorescence microscopy images of GFAP + immunolabelling (green) in WT and Kidins220f/f retinas. Nuclei are labelled with DAPI (blue). (B). Quantitative analysis of total retinal area occupied by GFAP + immunostaining (GFAP-RA). Data are mean ± s.e.m.; each data point denotes an individual measure of the GFAP-RA in retinal sections of WT and Kidins220f/f animals and were analyzed via Mann-Whitney U-test. ****p < 0.0001. Abbreviations: GFAP (Glial fibrillary acidic protein), ONL (Outer nuclear layer), OPL (Outer plexiform layer), INL (Inner nuclear layer), IPL (Inner plexiform layer), GCL (Ganglion cell layer). Upper panels: Scale bar 50 μm (20X); Lower panels with magnified images: Scale bar 25 μm (40X)

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Fluids and Barriers of the CNS

ISSN: 2045-8118