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Fig. 8 | Fluids and Barriers of the CNS

Fig. 8

From: Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival

Fig. 8

Kidins220-deficient retina presents an unexpected increase of AQP4 and low levels of VPS35. (A). Representative fluorescence microscopy images of AQP4 (red) and VPS35 (green) expression in WT and in Kidins220f/f animals. Nuclei are labelled with DAPI (blue). (B, C). Quantitative analysis of total retinal area occupied by AQP4+ (AQP4-RA) (B) and VPS35+ (VPS35-RA) (C) immunostaining in WT and Kidins220f/f mice. Data are mean ± s.e.m.; each data point denotes an individual measure of the AQP4-RA and the VPS35-RA in retinal sections of WT and Kidins220f/f animals and were analyzed via Mann-Whitney U-test. ****p < 0.0001. Abbreviations: ONL (Outer nuclear layer), OPL (Outer plexiform layer), INL (Inner nuclear layer), IPL (Inner plexiform layer), GCL (Ganglion cell layer). Scale bar 50 μm

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Fluids and Barriers of the CNS

ISSN: 2045-8118