Enlarged choroid plexus is linked with poorer physical function in rural older adults: a population-based study

Table 2 Associations of choroid plexus volume with SPPB summary score (n = 1170)

Choroid plexus volume as an exposure variable	β coefficient (95% confidence interval), SPPB summary score
Choroid plexus volume as an exposure variable	Model 1	Model 2
ChP volume, continuous	-0.29 (-0.42, -0.16)^**	-0.24 (-0.37, -0.11)^**
ChP volume, sex-specific quartiles^†
Q1 (n = 288)	0.00 (reference)	0.00 (reference)
Q2 (n = 295)	-0.32 (-0.65, 0.01)	-0.28 (-0.60, 0.05)
Q3 (n = 288)	-0.29 (-0.63, 0.05)	-0.27 (-0.61, 0.07)
Q4 (n = 299)	-0.65 (-1.01, -0.30)^**	-0.52 (-0.87, -0.17)^**
P for linear trend	< 0.001	0.007

Abbreviations: ChP, choroid plexus volume; SPPB, Short Physical Performance Battery
Note: Data were β coefficients (95% confidence intervals) of SPPB summary score associated with choroid plexus volume as a continuous variable (per 1-ml increase) and sex-specific quartiles derived from two different models. Model 1 was controlled for age, sex, education, and total intracranial volume; model 2 was additionally adjusted for smoking, alcohol intake, body mass index, physical exercise, hypertension, diabetes, dyslipidemia, APOE genotype, stroke, and disproportionately enlarged subarachnoid-space hydrocephalus
^†The cut-offs of quartiles for total choroid plexus volume in females were < 2.68 ml (Q1), 2.68–3.30 ml (Q2), 3.30–3.87 ml (Q3), and > 3.87 ml (Q4) and the corresponding cut-offs in males were < 3.72 ml (Q1), 3.72–4.49 ml (Q2), 4.49–5.10 ml (Q3), and > 5.10 ml (Q4)
^*P < 0.05, ^**P < 0.01

ISSN: 2045-8118